Copanlisib dihydrochloride ( BAY 80-6946 dihydrochloride )

Catalog No. M23560 CAS No. 1402152-13-9

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Product Name

Copanlisib dihydrochloride
Note

Research use only, not for human use.
Brief Description

Copanlisib dihydrochloride is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ).
Description

Copanlisib dihydrochloride is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Copanlisib dihydrochloride has superior antitumor activity and it also has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR.
Synonyms

BAY 80-6946 dihydrochloride
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3Kα;PI3Kδ;PI3Kβ;PI3Kγ;mTOR
Research Area

——
Indication

——

CAS Number

1402152-13-9
Formula Weight

553.4
Molecular Formula

C23H30Cl2N8O4
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

O=C(C1=CN=C(N)N=C1)NC2=NC3=C(C=CC(OCCCN4CCOCC4)=C3OC)C5=NCCN25.[H]Cl.[H]Cl
Chemical Name

——

1.Liu N, et al. Mol Cancer Ther. 2013, 12(11), 2319-2330.

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